Journal Article |
| Block K, Gorin Y. Aiding and Abetting roles in Cellular Transformation Nature Review Cancer 2012 Sep;12:627-637.
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| Nayak BK, Feliers D, Sudarshan S, Friedrichs WE, Day RT, New DD, Fitzgerald JP, Eid A, Denapoli T, Parekh DJ, Gorin Y, Block K. Stabilization of HIF-2a through redox regulation of mTORC2 activation and initiation of mRNA translation Oncogene (ePub ahead of Print) 2012 Aug;.
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| Shanmugasundaram K, Block K, Nayak BK, Livi CB, Venkatachalam MA, Sudarshan S. PI3K regulation of the SKP-2/p27 axis through mTORC2 Oncogene (ePub ahead of Print) 2012 Jun;.
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| Dey N, Das F, Ghosh-Choudhury N, Mandal CC, Parekh DJ, Block K, Kasinath BS, Abboud HE, Choudhury GG. microRNA-21 Governs TORC1 Activation in Renal Cancer Cell Proliferation and Invasion PLoS One 2012 Jun;7(6).
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| New DD, Block K, Bhandhari B, Gorin Y, Abboud HE. IGF-I increases the expression of fibronectin by Nox4-dependent Akt phosphorylation in renal tubular epithelial cells Am J Physiol Cell Physiol 2012 Jan;302(1):122-130.
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| Maalouf RM*, Eid AA*, Gorin YC, Block K, Escobar GP, Bailey S, Abboud HE. *Equally contributing authors. Nox4-Derived Reactive Oxygen Species Mediate Cardiomyocyte Injury In Early Type 1 Diabetes Am J Physiol Cell Physiol 2012 Jan;302(3):C597-C604.
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| Fitzgerald JP, Nayak B, Shanmugasundaram K, Friedrichs W, Sudarshan S, Eid AA, DeNapoli T, Parekh DJ, Gorin Y, Block K. Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production PLoS One 2012 Jan;7(1):30712-30712.
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| Sudarshan S, Shanmugasundaram K, Naylor SL, Lin S, Livi CB, Parekh DJ, Yeh IT, Sun LZ, Block K, Parekh, M.D. D, ONeill CF. Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2a Accumulation and Promotes Migration and Invasion PLoS One 2011 Jun;6(6):21037-21037.
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| Mandal CC, Ganapathy S, Gorin Y, Mahadev K, Block K, Abboud HE, Harris SE, Ghosh-Choudhury G, Ghosh-Choudhury N. Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation Biochem J 2011 Jan;433(2):393-402.
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| Eid AA, Ford BM, Block K, Kasinath BS, Gorin Y, Ghosh-Choudhury G, Barnes JL, Abboud HE. AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes J Biol Chem 2010 Nov;285(48):37503-37512.
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| Block K, Gorin Y, New DD, Eid A, Chelmicki T, Reed A, Choudhury GG, Parekh DJ, Abboud HE,. The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin Am J Pathol 2010 May;176(5):2447-2455.
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| Bondi CD, Manickam N, Lee DY, Block K, Gorin Y, Abboud HE, Barnes JL. NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts J Am Soc Nephrol 2010 Jan;21(1):93-102.
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| Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L. Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species Mol Cell Biol 2009 Aug;29(15):4080-4090.
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| Block K*, Gorin Y*, Abboud HE. *Equally contributing authors. Subcellular localization of Nox4 and regulation in diabetes Proc Natl Acad Sci U S A 2009 Aug;106(34):14385-14390.
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| Eid AA, Gorin Y, Fagg BM, Maalouf R, Barnes JL, Block K, Abboud HE. Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases Diabetes 2009 May;58(5):1201-1211.
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| Block K, Eid A, Griendling KK, Lee DY, Wittrant Y, Gorin Y (Corresponding Author). Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression J Biol Chem 2008 Aug;283(35):24061-24076.
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| Menini S, Iacobini C, Ricci C, Oddi G, Pesce C, Pugliese F, Block K, Abboud HE, Giorgio M, Migliaccio E, Pelicci PG, Pugliese G. Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation Diabetologia 2007 Sep;50(9):1997-2007.
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Abstract |
| Cadena, A, Velez, JA, Block K, Barnes JL, Wagner B. Temporal expression of Nox4 in wild type and platelet-derived growth factor receptor β-deficient embryonic kidneys; 2009 May. (Medicine Research Day 2009).
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| Gorin Y, Eid, Assaad Antoine, Block K, Lee, Duck-Yoon. Dysfunctional Endothelial Nitric Oxide Synthase Contributes to Diabetes-Induced Glomerular Mesangium and Endothelium Injury. (Abstract F-PO1339) American Society of Nephrology Renal Week 2008. Philadelphia, PA; 2008 Nov.
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| Eid AA, Gorin Y, Block K, Roman LJ. Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy; 2008 Jul. (17th International Symposium on Microsomes and Drug Oxidations, Saratoga, NY).
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