1. Education and Teaching -
During the first four years of my career (from 2001-2005), I spent over 75% of my time performing clinical research in chronic obstructive pulmonary disease and asthma. In 2005, my efforts shifted from research to teaching and I assumed the role of the Module Director of the Respiratory Section for the second year medical students. Through this role, I discovered that educating interprofessional students at all levels is my forte and is where my passion lies. I have focused my attention on excellence in education since this time. As a physician, I help hundreds of patients/families every year. As an educator, the number of patients/families I touch by way of educating healthcare professionals increases exponentially, and I believe that this is the way I can leave my imprint on society. Through innovative educational projects, I can translate medical education for interprofessional healthcare providers into practical, easy-to-understand, and applicable strategies to facilitate improvements in patient care in clinical venues at my institution and by the dissemination of our methods, throughout the United States.
A summary of my current and recent teaching and educational activities includes:
Local Educational Activities (San Antonio and Texas):
Curriculum development and revisions (for learners at multiple levels of training): I continue to develop and revise curricula for teaching (1) interns, residents, fellows, and faculty the pearls of reading chest radiographs and chest CTs, (2) pulmonary/critical care board review for internal medicine residents, (3) first year medical students topics in respiratory medicine, (4) fourth year medical students in pulmonary topics, (5) nurses, physicians assistants, respiratory therapists, and PharmDs about pulmonary diseases. I employ novel teaching techniques using multimedia, simulation, small-group case-based discussions, role-play, audience response system, and other methods to achieve specified learning objectives. I have pilot tested these advanced teaching strategies to educate students, residents, fellows, and faculty at the UTHSCSA, which has become an educational laboratory. This laboratory has allowed testing of these innovative techniques prior to disseminating them to national and international audiences.
National Educational Activities:
Leader/Chair of a collaborative interprofessional team to design and develop an educational curriculum for Continuing Education for primary care clinicians and other healthcare professionals: COPD: What Really Works? A Best Practices Workshop for Primary Care. I collaborated with pulmonologists, family physicians, respiratory therapists, doctorates in pharmacy, nurse practitioners, and educational specialists from the American College of Chest Physicians, a professional society of over 18,000 clinician members, to develop a state-of-the-art interactive, program that educates clinicians to recognize, diagnose, and manage COPD based on evidence-based guidelin |
2. Chronic Obstructive Pulmonary Disease (COPD) -
I specialize in many aspects of chronic obstructive pulmonary disease (COPD) including: research and clinical practice in the identification, work-up, diagnosis, evaluation, management, acute exacerbations of COPD (AECOPD), comorbidities (anxiety, depression, osteoporosis, heart disease), and respiratory infections. I have particular expertise in teaching about COPD to various levels of learners including: patients, caregivers, students, residents, fellows, faculty, primary care clinicians, pulmonary/critical care specialists, and other healthcare professionals (e.g., physicians, nurse practitioners, physician assistants, respiratory therapists, nurses, medical assistants, pharmacists, Pharm D, etc.). |
3. Integrated (Chronic) Care Model -
I have a particular interest and expertise in implementing the integrated (chronic) care model in patients with chronic obstructive pulmonary disease (COPD) and multiple morbidities. I have expertise in clinical implementation, research and collaboration through the VA Cooperative study, and teaching/education about this model at international meetings. |
| Date |
Description |
Institution |
# Students |
| 10/2012 - Present |
Individual Instruction |
American College of Chest Physicians |
|
|
| 10/2012 - Present |
Individual Instruction |
American College of Chest Physicians |
|
|
| 8/2012 - Present |
Chest radiographs for Cardiologists |
UTHSCSA and the STVHCS |
14 students |
| I teach the cardiology fellows and faculty about the basics of reading chest radiographs in patients with a variety of cardiac diseases. |
| 1/2012 - Present |
Chest Radiographs for the Cardiologist (Post-graduate: Fellows) |
UTHSCSA |
16 students |
| Interactive case-based lecture |
| 2/2008 - Present |
Harmful Effects of Smoking and Drugs on the Lungs |
Patient focus groups: STVHCS and UHS |
100 students |
| I facilitate and lead these discussions with patients with COPD and other tobacco and drug-related diseases about the harmful effects of these substances on the lungs. I provide practical points to help patients achieve abstinence. |
| 7/2007 - Present |
Diabetic Ketoacidosis for Interns |
UTHSCSA / VA |
40 students |
| Annual "chalk talk" interactive lecture |
| 7/2007 - Present |
Basics of Chest CT Interpretation: Combined Conference: Pulmonary Fellows and Faculty |
UTHSCSA and STVHCS and SAMC |
30 students |
| Interactive, case-based lecture (Annual) |
| 7/2007 - Present |
Basics of Chest Radiograph Interpretation: Combined Conference: Pulmonary Fellows and Faculty |
UTHSCSA and STVHCS and SAMC |
30 students |
| 2-hour interactive lecture on the basics of interpreting chest X-rays (Annual) |
| 7/2007 - Present |
Management of Chronic Asthma for Residents |
UTHSCSA / VA |
50 students |
| Annual interactive, case-based lecture |
| 4/2007 - Present |
Internal Medicine Board Review: Pulmonary Diseases (Parts 1-4) |
UTHSCSA |
40 students |
| Annual interactive case-based lectures |
| 3/2007 - Present |
COPD: A New Look at an Old Disease and the GOLD Guidelines for Medicine Residents |
UTHSCSA |
25 students |
| Annual case-based lecture for internal medicine residents |
| 2/2007 - Present |
Clinical Medicine III |
The University of Texas Health Science Center |
10 students |
| Co-Course Director - Internal Medicine Readiness Course ("Boot Camp") for fourth year medical students who plan to attend a 3-year internal medicine residence program. |
| 2/2007 - Present |
Clinical Medicine III |
The University of Texas Health Science Center |
10 students |
| Internal Medicine Readiness Course ("Boot Camp") for fourth year medical students who plan to attend a 3-year internal medicine residence program. I taught a variety of topics including: Basic understanding of indications and use of BiPAP and mechanical ventilation, basic interpretation of arterial blood gases, chest radiographs and CT scans, pulmonary, function tests, diagnosis and management of acid base disorders, acute dyspnea, acute respiratory failure, asthma exacerbations (inpatient and outpatient), cardiopulmonary arrest and managing patients during "code blue," chronic obstructive pulmonary disease exacerbations (inpatient and outpatient), diabetic ketoacidosis, dysrhythmias (tachy and brady arrhythmias), electrolyte disorders (hyper/hypo: sodium, potassium, magnesium, calcium, phosphorus), hypotension and use of vasopressors, pleural effusions/empyema, documentation issues, and intubation and airway management. |
| 1/2007 - Present |
Undergraduate Student Supervision |
University Health System |
|
|
| 9/2006 - Present |
Oxygen Delivery Devices: Which Device to Use and in What Setting for Interns and Residents |
UTHSCSA |
45 students |
| Annual interactive, hands-on education with cases and multiple oxygen delivery devices |
| 8/2006 - Present |
Feeding Tubes and Lines Confirmation of Placement by X-ray for Interns and Residents |
UTHSCSA |
45 students |
| Annual interactive lecture for Emergency Medicine Series |
| 7/2006 - Present |
Overview of Pulmonary Medicine for Clinical Nurse Specialists |
UTHSCSA |
10 students |
| Annual series of interactive lectures (3 hours) for Clinical Nurse Specialists in the School of Nursing on a variety of Pulmonary topics, including: Pulmonary physiology, Acute respiratory failure, Pneumonia, COPD, and Oxygen delivery devices. |
| 6/2006 - Present |
Chest Radiography for Practicing Clinicians |
American College of Physicians Board Review Small Group Interactive Series: 1 hour CME |
125 students |
| These are annual interactive lectures for the Board Review Course for the American College of Physicians. Participants are divided into 4 small groups and I use case-based examples to review basic and advanced reading of chest radiographs |
| 10/2005 - Present |
Critical Respiratory Care |
The University of Texas Health Science Center |
|
| I teach the respiratory therapy students who rotate through the medicine intensive care unit at University Hospital several times per month. This mainly includes bedside teaching, but I also teach by "chalk talks", which are small group, interactive, case-based sessions on a variety of topics such as 1. trouble shooting the ventilator, 2. systematic steps to safely extubate patients, 3. management of acute respiratory failure, 4. management of stridor and acute laryngeal edema, 5. Bilevel positive airway pressure, among other topics. |
| 10/2005 - Present |
IV Sedation/Pain Control |
The University of Texas Health Science Center |
10 students |
| I conduct interprofessional education with bedside teaching and using small, case-based scenarios/discussions during the medicine intensive care unit (MICU) rounds. The members of our interprofessional team include: nursing students, pharmacy students and residents, respiratory therapists, medical students, interns (from anesthesia, medicine, and other specialties), internal medicine residents, pulmonary/critical care fellows, and the nurses, dietitians, social workers, and respiratory therapists who are caring for our MICU patients. |
| 8/2005 - Present |
Adv Physical Diagnosis |
The University of Texas Health Science Center |
220 students |
| Course Director - Annual Pulmonary ACES Course: Pre-clinical teaching using patients with a variety of pulmonary diseases (i.e., very severe chronic obstructive pulmonary disease, pulmonary fibrosis, and/or post-lung transplant) to emphasize physical exam techniques that emphasize the identification and diagnosis of pulmonary problems. After significant encouragement and requests from the students, I developed, filmed, and posted on YouTube a video explaining tactile fremitus using cups, water, and a straw. This link can be viewed at :http://www.youtube.com/watch?v=uzgdaJCf0Mk. |
| 7/2005 - Present |
Recognition and management of complicated parapneumonic effusions for Residents |
UTHSCSA |
25 students |
| Annual interactive, case-based lecture |
| 7/2005 - Present |
Introduction to Reading Normal and Abnormal Chest CTs for Interns: 1 hour |
UTHSCSA |
20 students |
| Annual interactive lecture for interns |
| 7/2005 - Present |
Pearls of Reading Chest Radiographs for Residents: 3 hours (Parts 1-3) |
UTHSCSA |
25 students |
| Annual interactive lectures |
| 7/2005 - Present |
Introduction to Reading Normal and Abnormal Chest CTs for Residents: 1 hour |
UTHSCSA |
25 students |
| Annual interactive lecture for Residents |
| 7/2005 - Present |
Introduction to Reading Chest X-rays for Interns: 6 hours (Parts 1-6) |
UTHSCSA |
20 students |
| Series of 6 interactive lectures annually |
| 5/2005 - Present |
Pulmonary Disease |
The University of Texas Health Science Center |
40 students |
| A few times per year, I teach the respiratory therapy students and practicing respiratory therapists about a variety of pulmonary and critical care topics including: 1. COPD and asthma, 2. Chest radiography, 3. percutaneous tracheostomy, 4. sedation in the ICU, 5. interstitial lung disease, 6. pulmonary hypertension and venous thromboembolism, and a variety of other topics. |
| 1/2005 - Present |
Managing COPD: The GOLD Guidelines for Medicine Residents |
UTHSCSA |
40 students |
| Annual, interactive, case-based lecture |
| 9/2004 - Present |
Rotation Student Supervision |
UTHSCSA / VA / UHS |
|
|
| 4/2004 - Present |
Physician Lecture Series for Respiratory Therapists |
UTHSCSA |
45 students |
| Annual or bi-annual interactive lectures on respiratory and intensive care unit (ICU) topics such as chronic obstructive pulmonary disease, percutaneous tracheostomy, sedation in the ICU, weaning from mechanical ventilation, chest radiography, status asthmaticus |
| 7/2002 - Present |
Post-Doctoral Student Supervision |
UTHSCSA / VA |
|
|
| 8/2001 - Present |
Emergency Management of Asthma: Medicine Interns and Residents |
UTHSCSA |
45 students |
| Annual interactive lecture for Emergency Medicine Series |
| 7/2001 - Present |
Post Graduate Rotation Supervision |
UTHSCSA / VA / UHS |
|
|
| 7/2001 - Present |
Post-Doctoral Student Supervision |
UTHSCSA / VA / UHS |
|
|
| 7/2001 - Present |
Special Topic |
The University of Texas Health Science Center |
|
| Bronchoscopy Attending, 8-16 weeks (scheduled), 10-20 contact hours per week, direct supervision and teaching of 1-2 fellows. Topics include: bronchoscopy, bronchoalveolar lavage, cytology and sterile protected specimen brush samples, transbronchial and endobronchial biopsies, lymph node needle biopsies, cryotherapy, brachytherapy, tracheal/bronchial stent placement, tracheal/bronchial balloon dilation, etc. |
| 7/2001 - Present |
Clinical Chest Disease |
The University of Texas Health Science Center |
|
| Medicine Thoracic Clinic Attending, University Hospital-Downtown: 1/2 day clinic per week, 8-14 weeks, 5-6 contact hours/week, Direct supervision and teaching 3 pulmonary/critical care fellows, 2-3 internal medicine residents, 2-3 graduate (4th year medical school) students. |
| 7/2001 - Present |
Clinical Chest Disease |
The University of Texas Health Science Center |
|
| South Texas Veterans Health Care System, Pulmonary Clinic Attending: 1/2 day clinic per week for 14-18 weeks, 5-6 contact hours per week. Direct supervision and teaching 3-4 pulmonary / critical care fellows, 2-3 residents, and 2-3 graduate (4th year medical) students. |
| 7/2001 - Present |
Clinical Chest Disease Consultation Service |
The University of Texas Health Science Center |
|
| Pulmonary Consultant Inpatient Service Attending (University Hospital and the VA simultaneously): 8-12 weeks (scheduled), 30+ contact hours per week, 5 hours per week in preparation time. Direct supervision and teaching 1-2 pulmonary / critical care fellows, 2-3 residents, and 2-3 graduate (4th year medical) students each week. Topics include the work-up and management of pulmonary diseases in medicine, surgical, psychiatric, and Ob/Gyn patients, interpretation of pulmonary function tests, proper technique for chest tube placement (pigtail catheters, Cook catheters, large-bore chest tubes), etc. |
| 7/2001 - Present |
Pulmon/Critical Care-amva |
The University of Texas Health Science Center |
22 students |
| Medicine Intensive Care Unit Attending (at University Hospital or the VA Hospital, but cover both on weekends): 14-18 weeks (scheduled), 40+ contact hours per week, 5 hours per week in preparation time. Direct supervision and teaching 1-2 pulmonary/critical care fellows, 4-8 residents, 4-8 interns, and 2-4 graduate (4th-year medical) students each week. Bedside teaching (7 days/week) includes mechanical ventilation, placement and interpretation of vascular lines, airway management, other procedures (chest tubes, Sengstaken-Blakemore tubes, etc.) as well as didactic ICU lectures (30 minutes to 1 hour per day, 5 days/week). |
Journal Article |
| Nguyen HQ, Fan VS, Herting J, Lee J, Fu M, Chen Z, Borson S, Kohen R, Matute-Bello G, Pagalilauan G, Adams SG. Patients with COPD with Higher Levels of Anxiety are More Physically Active Chest 2013 Jul;144(1):145-151.
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| Maselli DJ, Adams SG, Peters JI, Levine SM. Management of asthma during pregnancy Ther Adv Respir Dis 2012 Nov;.
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| Adams SG, Pitts, Jennifer, Wynne, JoEllen, Yawn, Barbara P, Diamond, Edward J, Lee, Shuko, Dellert, Ed, Hanania, Nicola A. Effect of a Primary Care Continuing Education Program on Clinical Practice of Chronic Obstructive Pulmonary Disease: Translating Theory Into Practice Mayo Clinic Proceedings 2012 Sep;87(9):862-870.
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| Adams SG, Burguete, Sergio Rodrigo, Maselli Caceres, Diego, Yawn, Barbara P. Translating the New Gold Grading System Into Clinical Practice Lung Health Professional Magazine 2012 May;3(1):16-26.
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| Fan VS, Gaziano JM, Lew R, Bourbeau J, Adams SG, Leatherman S, Thwin SS, Huang GD, Robbins R, Sriram PS, Sharafkhaneh A, Mador MJ, Sarosi G, Panos RJ, Rastogi P, Wagner TH, Mazzuca SA, Shannon C, Colling C, Liang MH, Stoller JK, Fiore L, Niewoehner DE. A Comprehensive Care Management Program to Prevent Chronic Obstructive Pulmonary Disease Hospitalizations Annals of Internal Medicine 2012 May;156(10):673-690.
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| Hospenthal MA, Adams SG,. Obstructive Sleep Apnea in Chronic Obstructive Pulmonary Disease: The Overlap Syndrome Current Respiratory Medicine Reviews 2012 Apr;8(2):131-136.
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| Adams SG, Cohen, R, Hanania, NA. Networks: IPF Clinical Trials, NW Name Change, New Gold Grades: Airways Disorders Chest Physician 2012 Feb;7(2):26-26.
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| Maselli Caceres D, Adams SG, Peters JI. The role of anti-infectives in the treatment of refractory asthma Therapeutic Advances in Respiratory Disease 2011 Dec;5(6):387-396.
|
| Henao-Martinez AF, Fernandez JF, Adams SG, Restrepo C. Lung Bullae With Air-Fluid Levels, What Is the Appropriate Therapeutic Approach? Respir Care 2011 Oct;.
|
| Sonetti DA, Hospenthal AC, Adams SG. Integrated management strategies for chronic obstructive pulmonary disease Journal of Multidisciplinary Healthcare 2010 Sep;20(3):181-188.
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| Adams SG, Anzueto A, Briggs DD, Leimer I, Kesten S. Evaluation of withdrawal of maintenance tiotropium in COPD Respir Med 2009 Oct;103(10):1415-1420.
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| Adams SG, Anzueto AR. A pharmacotherapeutic approach to improving health-related quality of life for patients with chronic obstructive pulmonary disease Clin Pulm Med 2009 May;16(3):115-126.
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| Adams SG, Sanchez, J. Clinical Strategies in COPD RT Magazine 2007 May;:30-35.
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| Adams SG, Smith PK, Allan PF, Anzueto AR, Pugh JA, Cornell JE. Systematic review of the Chronic Care Model in chronic obstructive pulmonary disease prevention and management Arch Intern Med 2007 Mar;167:551-561.
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| Adams SG, Anzueto A, Pugh JA, Lee S, Hazuda HP. Mexican American elders have similar severities of COPD despite less tobacco exposure than European American elders Respir Med 2006 Nov;100:1966-1972.
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| Adams SG, Anzueto A, Briggs DD, Menjoge SS, Kesten S. Tiotropium in COPD patients not previously receiving maintenance respiratory medications Respir Med 2006 Jan;100(9):1495-1503.
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| Adams SG. Managing COPD to improve quality of life Drug Benefit Trends 2006 Jan;18(4):259-265.
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| Adams SG, Pugh JA, Kazis LE, Lee S, Anzueto A. Characteristics associated with sustained abstinence from smoking among patients with COPD Am J Med 2006 Jan;119(5):441-447.
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| Adams SG. Managing COPD: Acute Exacerbations. Part 2 J Respir Dis 2005 Jan;26:335-341.
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| Adams SG. Managing COPD: How to deal with the most common problems. Part 1 J Respir Dis 2005 Jan;26:284-289.
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| Adams SG, Anzueto AR. Antibiotic therapy in acute exacerbation of chronic bronchitis: The antibiotics. Part 2 Pulmonary Perspectives 2002 Jan;19:1-5.
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| Adams SG, Anzueto A, Anzueto AR. Antibiotic therapy in acute exacerbations of chronic bronchitis Semin Respir Infect 2000 Sep;15(3):234-247.
|
Book Chapter |
| Bourbeau J, Sharafkhaneh A, Adams SG. Chronic Care Approach to the Management of COPD. In: Nicola A. Hanania (Editor), Amir Sharafkhaneh (Editor). COPD: A Guide to Diagnosis and Clinical Management. New York City, NY: Humana Press; 2011. p. 283-298.
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| Adams SG, Anzueto AR. Acute Exacerbations of COPD. In: Nicola A. Hanania (Editor), Amir Sharafkhaneh (Editor). COPD: A Guide to Diagnosis and Clinical Management. New York City, NY: Humana Press; 2011. p. 191-210.
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Abstract |
| Abedi A, Velez MI, Restrepo MI, Anzueto AR, Adams SG. Severe Acute Respiratory Distress Syndrome (ARDS) Secondary to Sirolimus-Induced Pneumonitis in a Non-Transplant Patient; 2014 May. (Proceedings of the American J of Resp and Crit Care Med).
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| Zatikyan N, King P, Malave AJ, Adams SG. Symptoms with a Slippery Solution; 2014 May. (Proceedings of the American J of Resp and Crit Care Med).
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| Adams SG, Fan VS, Nguyen HQ, Borson S, Kohen R, Matute-Bello M, Pagalilauan G, Anzueto AR. Clinical Outcomes in Chronic Obstructive Pulmonary Disease are Associated with Perception of Dyspnea more than Exacerbation Risk or Disease Severity Measured by Lung Function; 2013 Oct. (CHEST).
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| Velez MI, Angel LF, Levine SM, Adams SG. "Spontaneous" Pneumothorax in a Patient with Severe Emphysematous Lung Disease; 2013 May. (American Thoracic Society International Meeting Abstracts; vol. 187, no. 1).
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| Adams SG, Pitts J, Wynne J, Yawn B, Diamond E, Lee S, Dellert E, Hanania N. Impact of a Reproducible, Interactive Continuing Education Program on Chronic Obstructive Pulmonary Disease on Clinical Practice of Healthcare Professionals; 2011 Oct. (CHEST; vol. 140, no. 4).
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| Adams SG, Pitts, Jennifer, Yawn, Barbara P, Wynne, JoEllyn, Diamond, Edward J, Hanania, Nicola A. An Interactive Continuing Education Program on Best Practice Recommendations for Chronic Obstructive Pulmonary Disease Care Improved Confidence, Knowledge, and Clinical Practice of Primary Care Clinicians; 2010 Oct. (CHEST; vol. 138, no. 4).
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| Adams SG, Melo J, Luther M, Anzueto A. Antibiotics are associated with lower relapse rates in outpatients with acute exacerbations of COPD; 2009 Nov. (CHEST; vol. 136, no. 5 Sup).
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Review Article |
| Adams SG. The Comprehensive Management of COPD: The Role of Disease Management. COPD 2009 A Physicians Perspective Multimedia Webcast 2009 May;.
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| Vines DL, Adams SG. Managing COPD Exacerbations in the Hospital and Home Clinical Foundations 2008 Dec;:1-7.
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Editorial |
| Adams SG, Peters JI. Amoxicillin/clavulanate vs placebo: more exacerbation cures, fewer recurrences in mild-to-moderate COPD Annals of Internal Medicine ACP Journal Club 2013 Mar;158(6):3-3.
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| Adams SG, Anzueto A, Briggs DD, Leimer I, Kesten S. Response to Dr. Tsakoks letter to the editor entitled "Comment on tiotropium" Respir Med 2010 Sep;104(9).
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| Adams SG. Airways Disorders: COPD as a Multisystem Disease Chest Physician 2010 Jun;5(6):12-12.
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| Adams SG, Braman, Sidney, Blonshine, Susan, Hanania, Nicola. Panel discussion: Applying comprehensive chronic care to impact acute exacerbations of COPD Clinical Foundations 2008 Dec;:7-12.
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Electronic/Web Publication |
| Adams SG. Women Who Quit Smoking Do Live Longer 2012 Oct. Available from: http://www.medpagetoday.com/PrimaryCare/Smoking/35605 . |
| Adams SG. WipeCOPD YouTube Channel: High-definition videos for patients: a. What is COPD b. How to use an Aerolizer c. How to use an Autohaler d. How to use a Diskus e. How to use a Flexhaler f. How to use a HandiHaler g. How to use a Metered D 2012 Jan. Available from: http://www.youtube.com/user/wipecopd?feature=results_main . |
| Adams SG. Ask UT Medicine: COPD, ear tubes raise questions San Antonio, TX; 2008 Nov. Available from: http://www.mysanantonio.com/health/columnists/ask_ut_medicine/Ask_UT_Medicine_COPD_ear_tubes_raise_questions.html . |
Not Specified |
| Henao-Martinez AF, Fernandez JF, Adams SG, Restrepo C. Lung bullae with air-fluid levels: what is the appropriate therapeutic approach? Respir Care 2012 Apr;57(4):642-645.
|
Federal |
| Funding Agency |
NIH |
| Title |
Genetic Epidemiology of Chronic Obstructive Pulmonary Disease |
| Status |
Active |
| Period |
9/2007 - Present |
| Role |
Co-Principal Investigator |
| Grant Detail |
Genetic Epidemiology of Chronic Obstructive Pulmonary Disease. The original local grant was approximately $1.2 million.
Renewal Pending- 7/1/2012-06/30/2017 |
| Funding Agency |
NIH |
| Title |
Depression and functional outcomes in COPD: Impact of genetics and inflammation |
| Status |
Active |
| Period |
2/2010 - 11/2014 |
| Role |
Co-Investigator |
| Grant Detail |
I am the local PI for this two-center study. Depression is highly prevalent among patients with COPD and is associated with adverse clinical outcomes. The overall goal of this proposal is to examine the impact of inflammation and genetic risk factors on depression in patients with severe COPD, and to assess the combined effects of inflammation, genetics, and depression on changes in functional outcomes. There is increasing evidence that COPD is associated with systemic inflammation that impacts other organ systems. High levels of systemic inflammatory markers have also been linked to increased risk of depression in both healthy and chronically ill populations. The neurotransmitter serotonin which is involved in the pathophysiology of affective disorders is regulated by the serotonin transporter (SERT) that controls reuptake of serotonin at brain synapses. Recent studies report that SERT polymorphisms are associated with depression, suggesting that variants of this gene may be important in determining
whether patients with COPD will develop depression
during the course of their disease. The preliminary data linking SERT polymorphisms with depression and data suggesting a relationship between inflammation, depression and COPD strongly argue for a large scale prospective study to critically test these relationships.
Therefore, the aims of this prospective study of patients with moderate to very severe COPD are to: 1) Examine the relationship between SERT polymorphisms with depression; 2) Examine the bi-directional longitudinal relationship between markers of systemic inflammation (CRP, IL-1ra, IL-6, IL-12, TNF-α, and IFN-γ) and depressive symptoms in COPD, and explore the role of exacerbations and SERT genotype in this relationship; and 3) Determine the relationship of depression, inflammation, and SERT genotype with decline in functional outcomes (six minute walk test distance, physical activity measured with accelerometers, dyspnea severity, and h |
Private |
| Funding Agency |
The Chest Foundation and The American College of Chest Physicians |
| Title |
Distinguished Scholar Award in Respiratory Health |
| Status |
Active |
| Period |
9/2010 - Present |
| Role |
Principal Investigator |
| Grant Detail |
This grant is for an educational project entitled WIPECOPD, which stands for Web-based Interactive Professional Education in Chronic Obstructive Pulmonary Disease. I have modified the "live" interactive COPD regional education programs entitled "COPD: What Really Works? A Best Practices Workshop for Primary Care" to develop an interactive web-based education for primary care clinicians (MD/DO, nurse practitioners, and physician assistants), respiratory therapists, phrarmacists, nurses, medical assistants, medication aids, etc. This on-line course is a way to disseminate evidence-based guidelines in an interactive format with practical examples of how the guidelines can be applied to clinical practice. In addition, the web technology will be able to reach a large audience, allow clinicians and other healthcare professionals to learn at their own pace as they have available time, and will be available for a refresher of important information as these learners encounter patients with particular problems. |
State |
| Funding Agency |
University of Texas System Patient Safety Committee |
| Title |
Web-based Interactive Professional Education in Asthma (WipeAsthma) Tool to Disseminate Best Practice Recommendations to Healthcare Professionals |
| Status |
Active |
| Period |
7/2012 - 6/2014 |
| Role |
Principal Investigator |
| Grant Detail |
The purpose of this project is to create/evaluate a multidisciplinary Web-based Interactive Professional Education in Asthma (WipeAsthma) program using our extensive experience with developing live interactive asthma and chronic obstructive pulmonary disease (COPD) courses and a Web-based Interactive Professional Education in Chronic Obstructive Pulmonary Disease (WipeCOPD) program that is currently under final revisions and reviews at the following private link: http://208.116.52.144/. Based on the data summarized in our needs assessment in asthma, the overall learning objectives of WIPEAsthma include:
1. Correctly diagnose and assess patients with persistent asthma
2. Translate best practice recommendations for asthma into clinical practice
3. Apply best practice recommendations for asthma in clinical scenarios
In creating and assessing this multidisciplinary web-based interactive professional education in asthma program (WIPEAsthma), we will address many of the limitations of other educational offerings and start to create a continuing professional development program as suggested by the Institute of Medicine. Our on-line course is a method to disseminate evidence-based guidelines in an interactive format with practical examples of how the guidelines can be applied to clinical practice. In addition, the web technology will be able to reach a large audience, allow clinicians to learn at their own pace as they have available time, will be available for a refresher of important information as clinicians encounter patients with particular problems with asthma care, and will provide real-time feedback to learners by comparing them to their peers. By assessing the actual impact of this web-based educational activity designed to disseminate best practices in asthma care according to the evidence-based guidelines into clinical practice of healthcare professionals, our understanding of the complexities of changing clinician behavior will be advanced. As described |
|
| Funding Agency |
|
| Title |
Linezolid In The Treatment Of Subjects With Nosocomial Pneumonia Proven To Be Due To Methicillin-Resistant Staphylococcus aureus |
| Status |
Complete |
| Period |
- Present |
| Role |
Co-Investigator |
| Grant Detail |
|